ORIEN NOVA Award Application

Welcome to the ORIEN NOVA Award Information Page

Key Information


The Oncology Research Information Exchange Network (ORIEN) is a unique alliance to integrate data sharing and collaborative learning to accelerate cancer research and care. ORIEN was founded by the Moffitt Cancer Center and The Ohio State University Comprehensive Cancer Center in May 2014, and now includes 17 members (ORIENCancer.org). The foundation of the alliance is the common Total Cancer Care® (TCC) protocol, a longitudinal surveillance study of cancer patients, which allows for lifetime consent to access clinical data, perform laboratory analysis of specimens, and the ability to re-contact the patient. Following patient consent, patients agree with the Member Institution to three basic principles:

  1. Follow the patient throughout their lifetime permitting sharing of data and information.
  2. Study the patient’s specimens
  3. Maintain contact with the patient.

The ORIEN Avatar Research Program was launched in 2016, which generates molecular (NGS) data on patients with high risk cancers and links longitudinal clinical data throughout a patient’s lifetime to learn and anticipate patient needs. With ORIEN Avatar, the pace of development can be accelerated by taking a proactive approach to study the molecular and clinical nature of a patient’s disease and anticipating needs for clinical trials. The results: reduced timelines, reduced costs and better outcomes for patients.

Through ORIEN, members collect and share clinical data and specimens for analysis and have access to robust molecular data to foster and enable translational research. M2Gen Opens in a new window has developed a network data model system to integrate data from multiple sources and institutions to support team science and address complex problems. Centrally managed by M2Gen Opens in a new window, the ORIEN system provides the ability to identify patients for target-based clinical trials, and to query the data system to conduct research projects.

ORIEN’s Patient Advisory Council supports the position that patients enrolled in the Total Cancer Care Protocol be informed of the necessity for data sharing and fostering collaboration among top scientists to promote progress in cancer care. The Advisory Council also endorses the development of a “forum” for patient education and how their donated data is being studied to support cancer research. As a means of “giving back” to patients who have consented to TCC, enrollment of patients in the Total Cancer Care Protocol offers patients increased probability of being matched to the most appropriate, precise, clinical trial.

Key Dates

April 4, 2018 Request for Application Issued
May 24, 2018 Letter of Intent (LOI) Due by 5:00 pm ET
June 13, 2018 Invitation to Apply Notification Sent to LOI Submitters
August 1, 2018 ORIEN NOVA Award Applications Due by 5:00 pm ET
September 12, 2018 ORIEN NOVA Award Peer Review Subcommittee Concludes Review & Selection
September 14, 2018 ORIEN NOVA Award Recipients Notified & Announced
September 15, 2018 ORIEN NOVA Funding Award Period Begins

For assistance with the letter of intent (LOI), please contact ORIENprojects@m2gen.com.